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E.MukherjeeD.AlqahtaniT.AlqahtaniS.BhattacharyaA.et al (2023)

A large review of 37 weight-loss studies found that people who rely solely on GLP-1 therapy tend to regain weight more quickly once treatment stops compared with those who also adopt behavioral changes

The peptides hormonal relevance remains theoretical and based on its effects on upstream factors (inflammation, vascular health, gut integrity) rather than direct HPG axis stimulation

Switching from one GLP-1 receptor agonist, like Semaglutide or Tirzepatide , to another requires careful planning to maintain the benefits of treatment while minimizing potential side effects especially those affecting the gastrointestinal system

Challenges such as medication affordability, insurance coverage limitations, and healthcare system barriers may affect accessibility